ASICS Womens GelKayano 23 Running Shoe White/Snow/Silver OtNuMgCiEv

B01NA73GBS
ASICS Womens Gel-Kayano 23 Running Shoe White/Snow/Silver OtNuMgCiEv
  • FluidFit/Mesh
  • Imported
  • Rubber sole
  • Shaft measures approximately Low-Top" from arch
  • I.G.S (Impact Guidance System) Technology: ASICS design philosophy that employs linked componentry to enhance the foot's natural gait from heel strike to toe-off.
  • FluidRide Midsole: FluidRide provides the ultimate combination of bounce back and cushioning properties with reduced weight and exceptional durability.
  • FluidFit Upper: ASICS FluidFit upper technology combines multi-directional stretch mesh with stretch reinforcements that adapt to the athlete's foot, creating a truly customized glove-like fit.
ASICS Womens Gel-Kayano 23 Running Shoe White/Snow/Silver OtNuMgCiEv ASICS Womens Gel-Kayano 23 Running Shoe White/Snow/Silver OtNuMgCiEv ASICS Womens Gel-Kayano 23 Running Shoe White/Snow/Silver OtNuMgCiEv ASICS Womens Gel-Kayano 23 Running Shoe White/Snow/Silver OtNuMgCiEv ASICS Womens Gel-Kayano 23 Running Shoe White/Snow/Silver OtNuMgCiEv

DC Womens Trase TX Skate Shoe Grey Ash ulvlumu

Advancing Innovative Strategies for Change in Behavioral Health
Skechers Sport Womens Microburst Supersonic Fashion Sneaker Navy/Green hybqT8

You are here

» News
News
By Dana Smith / Gladstone News / April 9, 2018
Yadong Huang and his team discovered how to erase the damage in human brain cells caused by apoE4, the primary genetic risk factor for Alzheimer’s disease

Using human brain cells, scientists at the Gladstone Institutes discovered the cause of—and a potential solution for—the primary genetic risk factor for Alzheimer’s disease, a gene called apoE4.

Having one copy of the apoE4 gene more than doubles a person’s likelihood of developing Alzheimer’s disease, and having two copies of the gene increases the risk by 12-fold, as compared to the most common version of the gene, apoE3.

The apoE4 gene creates a protein of the same name. The apoE4 protein differs from the apoE3 protein at only one point, but that single change is enough to alter its main structure and, thus, its function. Scientists have been unclear about why apoE4 is so much more damaging to brain cells than other versions of the protein.

In a new study published in , researchers revealed how apoE4 confers its risk for Alzheimer’s disease in human brain cells. What’s more, they were able to erase the damage caused by apoE4 by changing it, with a small molecule, into a harmless apoE3-like version.

A Better Model

Most Alzheimer’s research and drug development are done in mouse models of the disease. However, a succession of clinical trial failures has spurred scientists to turn to other models.

“Drug development for Alzheimer’s disease has been largely a disappointment over the past 10 years,” says lead author Yadong Huang, MD, PhD, a senior investigator and director of the Center for Translational Advancement at Gladstone.

“Many drugs work beautifully in a mouse model, but so far they’ve all failed in clinical trials. One concern within the field has been how poorly these mouse models really mimic human disease.”

Instead, Huang decided to use human cells to model the disease and test new drugs. Thanks to induced pluripotent stem cell technology, his team was able to examine, for the first time, the effect of apoE4 on human brain cells. To do so, the researchers created neurons from skin cells donated by Alzheimer’s patients with two copies of the apoE4 gene, as well as from healthy individuals who had two copies of the apoE3 gene.

The researchers confirmed that, in human neurons, the misshapen apoE4 protein cannot function properly and is broken down into disease-causing fragments in the cells. This process results in a number of problems commonly found in Alzheimer’s disease, including the accumulation of the protein tau and of amyloid peptides.

Notably, the presence of apoE4 does not change the production of amyloid beta in mouse neurons. But in human cells, scientists noticed apoE4 has a very clear effect on increasing amyloid beta production, which highlights the species difference in the way apoE4 controls amyloid beta metabolism.

“There’s an important species difference in the effect of apoE4 on amyloid beta,” says Chengzhong Wang, PhD, the first author on the paper and former research scientist at Gladstone. “Increased amyloid beta production is not seen in mouse neurons and could potentially explain some of the discrepancies between mice and humans regarding drug efficacy. This will be very important information for future drug development.”

Fixing a Toxic Protein

Once the scientists confirmed that apoE4 does, indeed, cause damage in human cells related to Alzheimer’s disease, a key question remained: how does the presence of apoE4 lead to cell damage? Is the presence of apoE4 resulting in a loss of normal apoE3 function, or does the addition of apoE4 cause the toxic effects?

“It’s fundamentally important to address this question because it changes how you treat the problem,” explains Huang, who is also a professor of neurology and pathology at UC San Francisco. “If the damage is caused due to the loss of a protein’s function, you would want to increase protein levels to supplement those functions. But if the accumulation of a protein leads to a toxic function, you want to lower production of the protein to block its detrimental effect.”

To answer this question, the researchers examined brain cells that did not produce either form of the apoE protein, and the neurons looked and functioned just like cells with apoE3. However, if the researchers added apoE4, the cells became riddled with pathologies related to Alzheimer’s disease. This discovery indicates that the presence of apoE4—and not the absence of apoE3—promotes the disease.

Finally, the researchers looked for ways to repair the abnormalities caused by apoE4. In earlier work, Huang and his collaborators developed a class of compounds that can change the structure of the harmful apoE4 protein so it resembles the innocuous apoE3 protein, referred to as apoE4 “structure correctors”.

Treating human apoE4 neurons with a structure corrector eliminated the signs of Alzheimer’s disease, restored normal function to the cells, and improved cell survival. Huang is now working with his collaborators in academia and the pharmaceutical industry to improve the compounds so they can be tested in human patients in the future.

Related News

Steve Madden Mens Syrcus LaceUp Black 1Pqjto8u
July 3, 2018
Amiana 15A5172 High Top Sneakers Silver Metallic Fog jQp3RO
April 12, 2018
Cell Therapy Could Improve Brain Functions Impaired by Alzheimer’s Disease
March 15, 2018
Gladstone Institutes Announces Research Collaboration with Lilly
December 7, 2017
XILALU Women Summer Casual AntiSlip Slipper Indoor Outdoor Sandals Beach Shoes Soft Foams Sole Pool Slippers Green o6uYztJgb
November 2, 2017

1650 OWENS STREET SAN FRANCISCO, CA 94158 415.734.2000

online $175.00

The Missouri Master Gardener Extension Program is “helping others learn to grow.” The Master Gardener program provides in depth horticultural training to individuals throughout Missouri who then volunteer their time applying what they have ...

Synthetic Auxin Herbicide Applicator Training Program (Non-Certificate Option)

online $0.00

This self-paced, online course is intended for general audiences who wish to better understand proper application of synthetic auxin herbicides such as 2,4-D and dicamba. This course is for informational purposes only. Participants will not receive a ...

Synthetic Auxin Herbicide Applicator Training Program

online $30.00

Attention pesticide companies: If you need to enroll several employees in this course, your employees will have to register separately in their own name and using a unique email address. Separate registration is required for certification and ...

CEU Equine Hind Limb Gait Abnormalities

March 5, 2018 - May 18, 2018

online $90.00

Taught by an associate teaching professor from the University of Missouri, the course aims to increase the depth of understanding of how the equine hind limb functions by examining five abnormalities: Fibrotic Myopathy, Patella Luxation, Upward ...

Horticulture for the Homeowner - Fall

Aug. 26, 2018 - Dec. 15, 2018

online $325.00

Horticulture entails the art and science of growing plants for both beauty and utility. Literally interpreted, horticulture means “to grow a garden”. A garden is a unique combination of site, soil, climate, and the plants that inhabit it. ...

View all online courses

HerStyle WomensAlerine Faux Suede Cut Out Thigh High Gladiator Black Zmd7c

External resources

Realtree Real Tree Marsh Jr Nzdt2lYs
Oak Decline

Learn about oak decline in this leaflet from the U.S. Department of Agriculture's Forest Service.

Don't Move Firewood website

Find out how far is too far to move firewood to avoid transporting invasive pests and diseases to new areas.

Pine Shoot Beetle (USDA APHIS)

For information on regulation of pine shoot beetles, visit the U.S. Department of Agriculture's Animal and Plant Health Inspection Service website.

Homeowner Treatments for Emerald Ash Borer

This video from Purdue University Extension describes how homeowners can use certain pesticide products for protecting ash trees against emerald ash borer.

United States Drought Monitor

The U.S. Drought Monitor, established in 1999, is a weekly map of drought conditions produced jointly by the National Oceanic and Atmospheric Administration, the U.S. Department of Agriculture, and the National Drought Mitigation Center at the ...

Missouri Urban Trees

This 60-page PDF from the Missouri Department of Conservation lists recommended trees for Missouri landscapes. It also describes how to select, buy, transport, plant and care for trees.

TOMS Mens Classic Canvas Slip On Ash VgllJNYV
View all Resources

Master Gardener

Provides in-depth horticulture training for Missourians who wish to spread their knowledge of gardening.

4-H Center for Youth Development

Providing hands-on learning and education so youth can build habits of responsibility, resiliency and hard work to succeed in life.

Soil and Plant Testing Laboratory

Analyzes soil, plant, water, manure, compost and greenhouse media.

AgrAbility

Assists people with disabilities who are employed in agriculture.

Annie's Project

Based on the life of Annette (Kohlhagen) Fleck, Annie’s Project empowers farm women to be better business partners through networks, managing and organizing critical information.

Century Farms

Awards certificates to landowners with farms that have been in the same family for 100 years or more.

All programs

ZINGYOU Men Leather Casual Flexible Slipon Loafers Moc Flat Driving Shoes Brown yxGMd6PPj

s​/​t

by NIKE Womens Free TR 7 Premium Training Shoe Black/Blackwolf Grey 728SoQ08md

Unable to save changes to your wishlist.
supported by
dslubbzz95
juice
Heather Levinsky
alec ciesla
Ruy De Magalhaes
ha_rim
power funeral
jamleb
eilish
Ryan Cox
daniel ciecko
Streaming + Download
Includes high-quality download in MP3, FLAC and more. Paying supporters also get unlimited streaming via the free Bandcamp app.
Purchasable with gift card

name your price

one gender then two, to many, too many, children and then bodies too. in naming histories a burnt down house in Queens, in reinventing them a dried up beach in Philadelphia. eventually dysphoric blood and Phil Elverum’s glow, but always and ultimately, nada y nada y nada y nada. Side A, tracks 1-10 entitled “FEAR NOT”, is an intimate record about the blood of our genders. Secrets secrets secrets. Side B, tracks 11-20 entitled “OURSELVES ALONE”, is an adventurous record about Phil Elverum. Glow glow glow. These records communicate with each other in the way they understand the histories inscribed on the other, with "FEAR NOT" being an attempt to name histories and "OURSELVES ALONE" being an attempt to reinvent them. Except for my bandmates’ parts tracked in their respective homes, this album was written and recorded with the big heart of DIY at The Closet Mansion in Queens, NY from January 2016-October 2017. Amidst discoveries and mistakes, there is perseverance, experience and endurance.
released February 14, 2018 FEAR NOT OURSELVES ALONE is: Ivan // Ivy - words, vocals, guitar, bass (tracks 1, 2, 5, 7, 10, 11, 12, 13, 14, 16, 19), drums (track 7), synthesizer, production, mixing Jon - guitar, album art Dan - bass (tracks 4, 6, 8, 15, 17, 18, 20), masterting Thank you to Nils for playing drums on tracks 4, 6, 8, 15, 17, 18, 20. Thank you to Sam for playing drums on tracks 1, 2, 5, 10, 11, 12, 13, 14, 16, 19. Thank you to Bryce for singing on track 3. This record is dedicated with all my love to Donald Grim, for introducing me to the blood of our genders and the beaches of Philadelphia. Recommended listenings: “The Glow Pt. 2” by The Microphones: pwelverumandsun.bandcamp.com/album/the-glow-pt-2 “nobody wouldn’t see good things” by Lemon Meringue Die: lemonmeringuedie.bandcamp.com “divorce lawyers i shaved my head” by jordaan mason and the horse museum: jordaanmason.bandcamp.com/album/divorce-lawyers-i-shaved-my-head This record would not exist without the aforementioned works. Mostly, “The Glow Pt. 2” by The Microphones from which much of Side B appropriates its lyrics. In the mode of a found poem, I aimed to make new art from this existing work. All rights to Phil Elverum, his words are not meant to be stolen, but to be used in understanding. “nobody wouldn’t see good things” by Lemon Meringue Die offered inspiration during a period of artistic drought, making beautiful the ways in which intimacy can be achieved through recording and how sampling Phil Elverum’s work can accomplish message. In thinking about the ways in which gender can serve as a means of introspection towards amalgamated histories, I am in debt to the brilliant work of jordaan mason. No art exists in vacuum, no artist in void. thank you // love each other, Ivan // Ivy
all rights reserved

Tags

Reebok Pro Ferocious AT 4E Football Mens Shoes Black/Whitepromo lCwWHGEGJ0
art rock bedroom pop closet music lo-fi New York

Shopping cart

Check out

FEAR NOT OURSELVES ALONE Queens, New York

Station Information

  • © 2018 The Mighty 790 KFGO - KFGO
  • People You Know. News You Trust

Listen

Contact

More